| ncRNA name | αB crystallin siRNA |
| ncRNA Category | siRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cells |
| Methods | siRNA transfection, immunocytochemistry, Western blot |
| Expression pattern | associated |
| Functional description | Generation of reactive oxygen species (ROS) was observed with NaIO3 in mouse and human RPE which increased further after αB crystallin knockout or siRNA knockdown. NaIO3 upregulated AKT phosphorylation and peroxisome proliferator-activator receptor-γ (PPARγ) which was suppressed after αB crystallin siRNA knockdown. |
| PubMed ID | 24874187 |
| Year | 2014 |
| Title | Protection of retina by αB crystallin in sodium iodate induced retinal degeneration. |
| Drug-related ncRNA | NO |
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